| Synonyms | calcium/calmodulin-dependent protein kinase type ii alpha chain; cam-kinase ii alpha chain; cam kinase ii subunit alpha; camk-ii subunit alpha; camk2a; camka; kiaa0968 |
| Sequence | Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu or KKALRRQETVDAL |
| Molecular Formula | C65H118N22O20 |
| Molecular Weight | 1527.8 g/mol |
| Purity | Purity > 95% by HPLC |
| Format | Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt. |
| Solubility | Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile. |
| Storage | Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C. |
| description | autocamtide-2 is a highly selective peptide substrate for calcium/calmodulin-dependent protein kinase ii (camkii), which belongs to the camk ser/thr protein kinase family. the sequence derives from the thr-286 autophosphorylation site of the alpha subunit of camkii. autocamtide-2 contains the r-x-x-s/t consensus site surrounded by basic residues for improved binding to phosphocellulose. camkii is a prominent kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. autophosphorylation of thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. camkii phosphorylates autocamtide-2 with a km of 2 um whereas protein kinase c (pkc) has a km > 50 um and protein kinase a (pka) has no activity. |
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1) Contact us at: Service@apichina.com ;2) Provide us peptides information including Sequence, Purity, Quantity and modification(If necessary, we agree to sign confidential agreement with you before you provide these information), we will make you a quotes within 30 minutes;
3) Place us a purchaser order, we can send you a sales contract too if you need;
4) Start synthesis, and we will inform you the updates of synthesis in time;
5) Arrange shippment, HPLC analysis, MS spectrum will be shipped along the peptides too;
6) Refund all pre-payment(if pre-pay us) if we failed to synthesize any of them;
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